Caractérisation rhéologique et transport du mucus bronchique par un appareil d’aide à la clairance mucociliaire (thèse: 2015 - 2018)
Activités
Étude de la rhéologie des mucus
Approche expérimentale et numérique
Publications scientifiques au M2P2
2018
L Valade, A. Ekedahl, P Ghendrih, Y. Sarazin, Y. Asahi, et al.. Electron burst driven by near electric field effects of lower-hybrid launchers. Contributions to Plasma Physics, 2018, 58 (6-8), pp.465-470. ⟨10.1002/ctpp.201700156⟩. ⟨hal-02196679⟩ Plus de détails...
Hot spot generation by Lower Hybrid (LH) launchers is found to be governed by a resonance in the plasma electric field response to the external drive. The kinetic analysis in 1D-1V in the parallel direction allows one to compute the amplification effect for small amplitude of the external drive. The resonant Lorentzian response distorts the distribution function with an island structure in the suprathermal part at the phase velocity of the external electrostatic drive. The non-linear features enhance the plasma response driving overlap effects between multiple waves at rather low amplitude. The onset of a plateau in the distribution function with extent up to one thermal velocity is already obtained when the standard overlap condition is achieved. The sensitivity of the resonance to plasma parameters and large variation of the amplification magnitude can compensate the fast radial decay of 1
L Valade, A. Ekedahl, P Ghendrih, Y. Sarazin, Y. Asahi, et al.. Electron burst driven by near electric field effects of lower-hybrid launchers. Contributions to Plasma Physics, 2018, 58 (6-8), pp.465-470. ⟨10.1002/ctpp.201700156⟩. ⟨hal-02196679⟩
Olivier Lafforgue, Isabelle Seyssiecq, Sébastien Poncet, Julien Favier. Rheological properties of synthetic mucus for airway clearance. Journal of Biomedical Materials Research Part A, 2018, 106 (2), pp.386 - 396. ⟨10.1002/jbm.a.36251⟩. ⟨hal-01678912⟩ Plus de détails...
In this work, a complete rheological characterization of bronchial mucus simulants based on the composition proposed by Zahm et al. [1] is presented. Dynamic Small Amplitude Oscillatory Shear (SAOS) experiments, Steady State (SS) flow measurements and three Intervals Thixotropy Tests (3ITT), are carried out to investigate the global rheological complexities of simulants (viscoelasticity, viscoplasticity, shear-thinning and thixotropy) as a function of scleroglucan concentrations (0.5 to 2wt%) and under temperatures of 20 and 37 °C. SAOS measurements show that the limit of the linear viscoelastic range as well as the elasticity both increase with increasing sclerogucan concentrations. Depending on the sollicitation frequency, the 0.5wt% gel response is either liquid-like or solid-like, whereas more concentrated gels show a solid-like response over the whole frequency range. The temperature dependence of gels response is negligible in the 20-37°C range. The Herschel-Bulkley (HB) model is chosen to fit the SS flow curve of simulants. The evolution of HB parameters versus polymer concentration show that both shear-thinning and viscoplasticity increase with increasing concentrations. 3ITTs allow calculation of recovery thixotropic times after shearings at 100s-1 or 1.6s-1. Empiric correlations are proposed to quantify the effect of polymer concentration on rheological parameters of mucus simulants.
Olivier Lafforgue, Isabelle Seyssiecq, Sébastien Poncet, Julien Favier. Rheological properties of synthetic mucus for airway clearance. Journal of Biomedical Materials Research Part A, 2018, 106 (2), pp.386 - 396. ⟨10.1002/jbm.a.36251⟩. ⟨hal-01678912⟩
Journal: Journal of Biomedical Materials Research Part A
Olivier Lafforgue, N. Bouguerra, Sebastien Poncet, Isabelle Seyssiecq, Julien Favier, et al.. Thermo-physical properties of synthetic mucus for the study of airway clearance. Journal of Biomedical Materials Research Part A, 2017, 105 (11), pp.3025-3033 ⟨10.1002/jbm.a.36161⟩. ⟨hal-01596484⟩ Plus de détails...
In this article, dynamic viscosity, surface tension, density, heat capacity and thermal conductivity, of a bronchial mucus simulant proposed by Zahm et al., Eur Respir J 1991; 4: 311–315 were experiementally determined. This simulant is mainly composed of a galactomannan gum and a scleroglucan. It was shown that thermophysical properties of synthetic mucus are dependant of scleroglucan concentrations. More importantly and for some scleroglucan concentrations, the syntetic mucus, exhibits, somehow, comparable thermophysical properties to real bronchial mucus. An insight on the microstructure of this simulant is proposed and the different properties enounced previously have been measured for various scleroglucan concentrations and over a certain range of operating temperatures. This synthetic mucus is found to mimic well the rheological behavior and the surface tension of real mucus for different pathologies. Density and thermal properties have been measured for the first time.
Olivier Lafforgue, N. Bouguerra, Sebastien Poncet, Isabelle Seyssiecq, Julien Favier, et al.. Thermo-physical properties of synthetic mucus for the study of airway clearance. Journal of Biomedical Materials Research Part A, 2017, 105 (11), pp.3025-3033 ⟨10.1002/jbm.a.36161⟩. ⟨hal-01596484⟩
Journal: Journal of Biomedical Materials Research Part A
Hugo Bufferand, G. Ciraolo, P Di Cintio, N Fedorczak, Ph Ghendrih, et al.. Nonlocal heat flux application for Scrape-off Layer plasma. Contributions to Plasma Physics, In press. ⟨hal-01655295⟩ Plus de détails...
The nonlocal expression proposed by Luciani-Mora-Virmont is implemented into a 1D fluid model for the scrape-off layer. Analytic solutions for heat equation are discussed as well as the impact of sheath boundary conditions on the continuity of the temperature profile. The nonlocal heat flux is compared to Spitzer-Härm heat flux for different collisionality.
Hugo Bufferand, G. Ciraolo, P Di Cintio, N Fedorczak, Ph Ghendrih, et al.. Nonlocal heat flux application for Scrape-off Layer plasma. Contributions to Plasma Physics, In press. ⟨hal-01655295⟩
Eric Serre, Sandrine Hugues, Emilia Crespo del Arco, Anthony Randriamampianina, Patrick Bontoux. Axisymmetric and three-dimensional instabilities in an Ekman boundary layer flow. International Journal of Heat and Fluid Flow, 2001, 22 (1), pp.82-93. ⟨hal-01023080⟩ Plus de détails...
Eric Serre, Sandrine Hugues, Emilia Crespo del Arco, Anthony Randriamampianina, Patrick Bontoux. Axisymmetric and three-dimensional instabilities in an Ekman boundary layer flow. International Journal of Heat and Fluid Flow, 2001, 22 (1), pp.82-93. ⟨hal-01023080⟩
Journal: International Journal of Heat and Fluid Flow
